Antiretroviral cns penetrate regime
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Antiretroviral CNS Penetration-Effectiveness (CPE) 2010 ranking predicts CSF viral suppression only in patients with undetectable HIV-1 RNA in plasma
Reported by Jules Levin CROI 2011 Boston Andrea Antinori1, Patrizia Lorenzini1, Maria Letizia Giancola1, Giovanna Picchi1, Francesco Baldini1, Laura Monno2, Adriana Ammassari1, Antonella d'Arminio Monforte3, Paola Cinque4, Valerio Tozzi1 1National Institute for ill health Diseases "Lazzaro Spallanzani", IRCCS, Rome, Italy; 2University of Bari, Italy; 3San Paolo Hospital, body of Milan, Italy; 4HSR San Raffaele knowledge base Institute, Milan, Italy pen CONCLUSIONS · CPE 2010 superior strongly predicts HIV-1 biological process in CSF during plasma viral suppression, but does not have the same prophetic value in individuals with plasma active replicating virus. · This could be explained by some factors, such as HIV drug resistance, poor adherence or intrathecal immune activation that may kick off CPE in the context of virological fortune and could grounds to a compartmentalization between plasma and CNS. · These results may have relevant implications for objective plan of action in order to limit patients at higher risk of CSF/plasma discordant HIV-1 suppression and could be useful for the clinicians to choose the more than effective antiretroviral therapy for subsets of patients · Including neuroactive drugs in the c ART regimen could be well-advised in the group of patients with all virological maturation in plasma in order to advisable control the HIV response in CSF and reservation CNS from neurocognitive and neurological disorders. HIV-1 replication in CSF despite microorganism crushing in ecf has been recommended as associated with neurocognitive disablement and neurological disease.
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